Background: Mutations in low-density lipoprotein (LDL) receptor (LDLR) are one of the main causes of familial hypercholesterolemia, which induces atherosclerosis and has a high lifetime risk of cardiovascular disease.The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system is an effective tool for gene editing to correct gene mutations and thus to ameliorate disease. Expression of a Bcl2 transgene allowed for partial rescue of B cell development, however, the majority of the rescued B cells had low surface immunoglobulin expression with evidence of ongoing light chain editing. All of these original systems were slow, cumbersome, and had problems with the limited computer horsepower of the time, but the mid-to-late-1980s saw a trend towards non-linear editing, moving away from film editing on Moviolas and the linear videotape method using U-matic VCRs. Computer processing advanced sufficiently by the end of the '80s ... The Valentine's Day report had chapters on basic research, somatic genome editing, heritable (germline) genome editing, enhancement, and public engagement. It offered clear, and strong, conclusions on germline genome editing: ‘In particular, clinical trials using heritable germline editing should be permitted only if done within a regulatory ... While returning from a project meeting and staring out of the train's window I had the idea how we could combine the ``best of both worlds'' for collaborative text editing: by adding change tracking and note facilities to LaTeX! This is the basic idea of the TrackChanges LaTeX package. But this is only one part of the change tracking ... First Sickle Cell Patient Treated With CRISPR Gene-Editing Still Thriving. Rob Stein, NPR, December 31, 2021. For more than a year, Victoria Gray’s life had been transformed. Gone were the sudden attacks of horrible pain that had tortured her all her life. Gone was the devastating fatigue that had left her helpless to care for herself or her ... Create a personalized photo to art transformations and unique gifts from our wide selection of products. Doozypics is the best online photo to art and gifts portal, providing digital paintings, caricature art & many more. Shop now for amazing discounts and get free shipping all over India. The CTX001 infusion, which consisted of two manufacturing lots, had allelic editing frequencies of 82.6% and 78.7%, respectively. After the administration of CTX001 and over time, ... To keep your photo editing mojo rolling, check out Google Photos Editor. Why? Since joining Google in 2010, the Picnik team has been working on Picnik while helping to create photo editing magic in Google's products. But now we get to focus. What about my photos saved on other sites? The twins, called Lulu and Nana, reportedly had their genes modified before birth by a Chinese scientific team using the new editing tool CRISPR. The goal was to make the girls immune to infection ...
2022.01.28 12:54 I-h8-my-life- the editing is horrible but I had to
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2022.01.28 12:54 hiru9 New Members Intro
2022.01.28 12:54 jasperis145 Thought on potential problems with MSRs?
I have been interested in molten salt reactors for while now but have mostly heard the benefits of the technology. I found this article that talks about intrinsic problems with this type of reactor:
I was wondering if anyone with a better understanding of the technology could comment on the accuracy of these statements and if this truly means that MSRs have no future? Thanks!
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2022.01.28 12:54 moreprivacyplz The Privacy, Security, & OSINT Show: 248-Privacy vs. COVID
The Privacy, Security, & OSINT Show: 248-Privacy vs. COVID https://soundcloud.com/user-98066669/248-privacy-vs-covid
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2022.01.28 12:54 Substantial_Raisin53 Join the Shadow Ages discord for WL spots and free NFT giveaways for their upcoming p2e game on wax. 💯
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2022.01.28 12:54 yuki_hates_rape I thought bread was verboten?
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2022.01.28 12:54 deniss_1996 Augason Farms: 1lb. 7oz. can Dehydrated Potato Shreds $8.14, 3lb. Can Potato Gems Mashed Potatoes $14.88 + Free Shipping w/ Prime or on $25+
2022.01.28 12:54 FancifulFem Anyone else find it annoying when people can't tell the difference between a femboy and trans woman?
I've been posting content on other subs and it's gotten annoying the amount of people that seem to think I'm a trans woman. Obviously there'd be nothing wrong with being a trans woman. But it gets annoying when people just assume I'm trans because I look feminine and wear feminine clothing.
What gets really insulting is when people not only think you're a trans woman, but then fetishize you as one. That's just fucking... ew. Making bad assumptions not only of your identity but the idea that if you were you'd just be okay being fetishized like that.
Anyone else experience/feel this sentiment? Maybe I've just got a stick up my ass or maybe this just isn't talked about a lot.
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2022.01.28 12:54 mathismei Hello quick question
I’m new to all This stuff so sorry if it’s the wrong subreddit but basically i want to put a 3d model like the one from that site on a static image but idk witch program to use i have photoshop but is there like a better one? Also is there a better website for free 3d effects? Thank you
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2022.01.28 12:54 ProsteProfik Pls
2022.01.28 12:54 The-Male-G-Spot The term "expat" is ridiculous, and entirely unnecessary.
So I've learned of this term in the last few days, and for those that don't know, its concrete definition is:
a person who lives outside their native country.Which ya know, has already been labelled for quite a while.
2022.01.28 12:54 BadaB00mBabay NoLaw образовательный:) Слово «торрент» происходит от названия древнеримского города Тарент - оплота пиратов и контрабандистов. Считается, что в ответ на очередное повышение тарифов торговец Юний произнёс ставшую крылатой фразу: «Sic habitus - modo Tarentum!» («С таким отношением только Тарент!»)
Давненько я не писал о своих приложениях на телефоне...
Всё вы пользуетесь торрентами (да да, и не пиздите мне тут). Чаще всего это приложение uTorrent, так ведь?
А я вот пользуюсь приложениями MediaGet для телефона и компа, причём на компьютере более широкий функционал.
Конкретно я использую именно его, поскольку uTorrent даже в версии Pro не всегда подхватывает magnet-ссылки, а чтобы скачать сам файл с расширением .torrent сайты очень часто требуют регистрацию.
В MediaGet же, даже в самой начальной версии и без регистрации доступен практически весь функционал, включая воспроизведение уже в процессе закачки.
Но может кому-то из вас будет интересна другая фишка - каталог фильмов, сериалов и мультиков с фильтрами по жанрам, годам, рейтингу, новизне, а также языку и субтитрам для изучающим их иностранный язык или предпочитающих смотреть с оригинальной озвучкой.
Регистрация же, позволит вам подписаться на сериал, например и получать уведомления сразу с сылкой на скачивание новой серии, как только ко она появится на одном из торрент-ресурсов
Ну а для того, чтобы вас пускали на заблокированные Роскомнадзором торренты типа Rutor, а также была доступна вся заблокированная им же порнуха;)) - просто сделайте маааленькую нас троечку в телефоне:
Настройки -> Подключение и общий доступ -> Частный DNS-сервер
И напишите, как вот на этом скрине: dns.adguard.com
Теперь вы кроме получения расширенного доступа к заблокированному контенту ещё и не будете получать в браузере телефона тонны рекламы:)
Всём спасибо за внимание, друзья. С уважением, ваш Бабай
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2022.01.28 12:54 doko-jihn Laughter
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2022.01.28 12:54 Codeb-Brefast301 Represent
2022.01.28 12:54 SUPERGOOCH9293 OP-1 Live Looping
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2022.01.28 12:54 ConrailFanReddits Flag of the United States of America (USA) but the only state that really matters
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2022.01.28 12:54 MissingMyPrinter Missing Printer!
As title stated I lost my printer a couple days ago at laz. It’s a Golden AWD HP Ecotank with a Core i9-9900k, RTX3090, 11-inch 1920:1080 screen, Enhanced 4K camera with dual monitor capabilities, and equipped with the latest android version.
If you find it or have it, please shoot me a DM asap since I need to print off my business proposal and multiple different resume templates!
Thanks in Advance, The BBA Student who lost his printer
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2022.01.28 12:54 cowking010 Can my workplace not allow water in the backroom?
Hi, I have recently been informed at our workplace we aren't allowed to set a water bottle down in our backroom anymore. Now I must preface saying, I've worked at three different stores in this particular corporate chain, and never had a problem getting to water. But recently here, Market came down and said we arent allowed to set down a water bottle in the backroom. We can have them on our carts or in our pockets. For my particular job title, I don't have a cart, ever. And (even ignoring the giant hole in my uniform pocket and they refuse to give me a new one, because the only person that can give me a new one works days and I work nights) I keep a lot of stuff in my work pockets anyway, like my medications, work equipment, pens and sharpies for my work, and so on. Realistically, I cannot keep a water in my pocket (even with a new uniform) because of all the other things in there. Also, I only leave the backroom once every 4–6 hours depending on the day. I live in Florida, some of my job is outside. So my question is, how often should I be allowed to get water? Theoretically I am supposed to get a break every two hours but that never happens, but even if I did going two hours without water would be the equivalent of hiking for two hours without water.
How often are employers required to allow water breaks, if we arent allowed/can't keep water with us?
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2022.01.28 12:54 powerofmateo GG Low Level Dueling Amulet or Charsi Food?
2022.01.28 12:54 stormfiredsquid A fire ball in a never ending tunnel of grey
2022.01.28 12:54 ladyjcreative Van/kidnapper
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2022.01.28 12:54 bouchandre Thoughts on this graph? Is it accurate?
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2022.01.28 12:54 DeezYanks NSFW: Animal skull found in NY woods. What is it?
2022.01.28 12:54 UGLVARPG How recently do I have to have worked to be eligible for SSDI?
I haven’t worked in six years. Recently someone indicated I have to have worked in the last five years. Doing a web search I found:
“Most SSDI recipients need to have worked recently, usually any 5 of the past 10 years. If you have worked intermittently, but have earned income within the past couple of years, you may be eligible for Social Security disability benefits.”
I don’t know if it’s accurate.
I haven’t found an answer here:
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2022.01.28 12:54 rharmelink Newly Free Romance Kindle Book Lists for 2022-01-28