Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis (Published: 2022-01-13)

2022.01.22 11:58 Ricosss Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis (Published: 2022-01-13)

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00635-500635-5)
Highlights

Summary Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This comprehensive atlas of exercise metabolism provides clarity and physiological context regarding the production and distribution of canonical and novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), and reveals insight into the health-promoting benefits of exercise on metabolism.
Authors:
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2022.01.22 11:58 Aziz0161 [OC] The original 12 seasons (from Mars to February) depicted on a mosaic in the Sousse archeological museum [3024x4032]

[OC] The original 12 seasons (from Mars to February) depicted on a mosaic in the Sousse archeological museum [3024x4032] submitted by Aziz0161 to ArtefactPorn [link] [comments]


2022.01.22 11:58 dayasoftsl Mini Vest for women $9.85

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2022.01.22 11:58 Sfreeman1 From the Canadian shores of Lake Huron.

From the Canadian shores of Lake Huron. submitted by Sfreeman1 to pics [link] [comments]


2022.01.22 11:58 Jillanthropist 🙃🙃🙃

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2022.01.22 11:58 Mollythepusscat 🔥 How simply beautiful is this singular snowdrop

🔥 How simply beautiful is this singular snowdrop submitted by Mollythepusscat to NatureIsFuckingLit [link] [comments]


2022.01.22 11:58 aliveli2 German Navy Chief in Delhi says germany needs russia against china, and he adds he is a god-believing christian and russia is a christian country

German Navy Chief in Delhi says germany needs russia against china, and he adds he is a god-believing christian and russia is a christian country submitted by aliveli2 to GenZedong [link] [comments]


2022.01.22 11:58 christopher-reid (updated) A Map of the Three Regions

(updated) A Map of the Three Regions submitted by christopher-reid to worldbuilding [link] [comments]


2022.01.22 11:58 Zoomorph23 Trying to Crowd Fund a refund?

Trying to Crowd Fund a refund? submitted by Zoomorph23 to AmazonAnswers [link] [comments]


2022.01.22 11:58 Shoddy-Team-7199 Dr stone fans

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2022.01.22 11:58 TotalKrieger Really?

I know i wasnt perfect i made mistakes. But this is the end? It was so horrible? Im bloody drunk, do you eve believe what you told me? I gavebup for so much so we will be happy, my depression took a toll i know, but am i not worth a second chance? When we were abroad in a pool, when you were with me when my grandma died, every moment you cried aand i tried to help you with everything, am i really so controlling? Wasnt i worth at least a talk? Was the year fake? Everything fake and false?
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2022.01.22 11:58 lotsofblue Santino Marella mispronouncing wrestlers' names

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2022.01.22 11:58 butiass Oh god no

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2022.01.22 11:58 Chryxz Will these SSDs work with my Asus TUF Gaming Z590-PLUS WIFI ATX LGA1200 Motherboard?

I'm buying the
Western Digital WD_BLACK SN750 1 TB M.2-2280 NVME Solid State Drive
&
Samsung 980 Pro 2 TB M.2-2280 NVME Solid State Drive
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2022.01.22 11:58 Dr_celtic1 My Return To The Gold Tooth. FANTASTIC SEQUEL TO THERES A BAR IN NEW YOTL YJAT ONLY I CAN SEE. WRITTEN BY THE FANTASTIC SUSPICIOUS NAIL.

https://youtu.be/5gx1Yk641rM
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2022.01.22 11:58 DKBetiza Recent picture updates to AEW's website roster

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2022.01.22 11:58 CrystalOcean39 Anyone here able to do my GP's job and help me out?

I saw a different GP than usual at my latest appointment and I am finding managing my pain and symptoms hugely difficult...
I currently am prescribed 2 x 30/500 cocodamol per day plus naproxen.
I can't take the co-codamol as often as prescribed due to the constipating side effects and same with naproxen as it irritates my stomach and increase other symptoms I'm having such as nausea, reflux etc. Insomnia due to my PMDD (or possible perimenopause) is also debilitating.
I was at my wits end and sobbed through my appointment explaining all of this. I explained I need alternative pain meds.
The Dr just shared at me as if I was play acting and said ' Well, what medication do you suggest?'. What others have helped?.
I thought that was HER job?
I've been given a prescription for anti depressants which I neither want or need.
Can anyone tell me what pain meds help them so I can at least suggest an option the next time I have to call which will likely be this week...
Thanks in advance.
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2022.01.22 11:58 fatherx50 At 2:30 in the morning the alarm system goes off

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2022.01.22 11:58 Sean_Feesh Help! Jade tree suddenly started slouching.

Help! Jade tree suddenly started slouching. submitted by Sean_Feesh to houseplants [link] [comments]


2022.01.22 11:58 AlN3rd Opinions on tracing the 3D models

This is probably my anxiety getting the better of me, but sometimes I feel like I'm cheating when I trace the poses from the 3D models and don't just set them off to the side to use as reference. I figured I'd feel better asking about it, so what's you guys' opinion on it?
View Poll
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2022.01.22 11:58 mgragg0703 Two little sisters loving this snow!

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2022.01.22 11:58 KoMoDoJoE98 Does anyone else hate spiderwebs?

In theory yeah I love it. I played from S2-7 or something so I was there for the grapple hook and loved that but the spiderman gloves are just ridiculous. Trying to shoot people as they swing through the air multiple times in a row is so tough on console. Saying that after a fair few games back too so it's not just my rusty aim (I swear!)
Often lose almost-dead people to this or will get pushed with it. Especially frustrating when you have high-ground in final circle and you just hear "psshhhh". Look around to see where they are and theres a guy suddenly in your one by one unloading shotgun into you.
Sorry for the moan (im really enjoying playing again despite this feature) but any suggestions on how to combat the gloves would be hella appreciated. Cheers
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2022.01.22 11:58 badvibes1984 Trickle down economics

Can someone eli5 trickle down economics and why it doesn't seem to ever happen. My old boss got tons of money in covid loans and that shit never trickled down to me or my coworkers. In fact after he got that money he fires half of us because he "couldn't afford to pay us"
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2022.01.22 11:58 assafstone The ending of Winter’s Heart

I don’t know if I’m the only one, but while the Far Madding section was nice and interesting (I liked the first insight into Cadsuane), the cleansing, which I think was supposed to be the climax of at least this book (if not the previous few leading up to it), was underwhelming.
I’ve read the series several times now, and I cannot help but thinking that the act of using the Chodan Kal for cleansing Saidin should have been more detailed; I wanted more from Rand and Naeneve’s POV on it (more than I got), not just the fights around it. That felt more like a video game of keep away, with waves of enemies to defeat or hold off.
Is it just me? Or do others feel like that?
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2022.01.22 11:58 trailer8k Asmongold meets Chris Hansen

Asmongold meets Chris Hansen submitted by trailer8k to funnyvideosyoutube [link] [comments]


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