2021.10.16 01:04 EruditePolymath Bacopa Interfering with Xanax Metabolization via Inhibition of Cytochrome P450
With Bacopa, the usual fear is that, by inhibiting cytochrome P450, it can prevent the metabolization and thus the elimination of certain antidepressants and anti-psychotics, leading to a potential overdose. 
 See: "Bacopa Side Effects" https://www.superfoods-scientific-research.com/medicinal-herbs/bacopa-side-effects.html
However, I found nothing regarding bacopa and xanax despite search on numerous search engines. However, it is my personal experience that bacopa interferes with the metabolization of xanax (which I take on rare ocassions for chest pains and panic attacks).
Alprazolam (xanax) is metabolized by Cytochrome P450 into alpha-hydroxy alprazolam (alpha-OHALP, pharmacologically more active) and 4-hydroxy alprazolam (4-OHALP, pharmacologically less active). 
I've been taking Bacopa for a few days now, and I just tried taking xanax for an acute case of anxiety, and I felt nothing. Took a second xanax an hour later. Still felt NOTHING.
So I suppose I'll need to discontinue Bacopa despite its blood flow improving and neuroprotective effects against the type of damage benzodiazipines can do to the brain. Luckily, I take other neuroprotective supplements (like Gingko Biloba and Acetyl-L-Carnitine) that do not interfere with Cytochrome P450 activity.
So, just a warning: if you are prescribed xanaz (i.e. alprazolam) for panic attacks or for chest pains (angina) resulting from hypoxia (lack of blood flow, which can be induced by extreme stress or anxiety), you likely want to avoid taking Bacopa as it will interfere with your metabolization of the drug. It may still work to some degree, I don't know, perhaps in a few hours I'll feel it kick in. I'll report back later with any changes.
But yes, two hours later, and I can't feel it and my anxiety is still here an hour later and my chest pains had to be subdued with nitroglycerin. So, yes, if you take any other prescription drug that is critical for your life or well being, be very wary of Bacopa because it's not thoroughly well researched and we don't yet know all the ways it changes how specific prescription medications and other supplements may be metabolized. It may also inhibit other metabolic enzymes. We simply don't know yet with the current literature.
I'll have to be content with my valerian root, lemon balm, passion flower, and chamomile, which are all anxiolytic and improve sleep, until the Bacopa gets out of my system. Luckily I wasn't experiencing a panic attack and I have my nitroglycerin as a backup for my chest pains (though, I cannot take it too often or it builds up tolerance and becomes inneffective, so I usually save it more severe cases of hypoxic pain so it will be as potent as possible.)
I read that Bacopa may interfere with the metabolization of certain drugs, so I was afraid to take it, but I tried it and it gave me very beneficial effects for the first few days. My actual concern was that it might make my alprazolam too potent, which wasn't too big a concern as I only take 0.5mg and if it lasted too long in my system, the worst case scenario I imagined is that it would put me to sleep and I'd wake up groggy the next day. I didn't imagine it might prevent alprazolam from working properly by preventing it from being metabolized into alpha-hydroxy alprazolam (alpha-OHALP).
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2021.10.16 01:04 jakethesnakeisback16 Shadow Of The Damned - RPCS3 [PS3 Emulator] - Core i7 4790 | RX-570 4GB
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2021.10.16 01:04 NokiaRingtone1o1 My Candara
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2021.10.16 01:04 Altruistic-Spinach-2 What’s your worst job experience
I was a contractor for a large tech company and it was honestly the worst job I’ve ever had. The people were nice and I made a couple of friends but the job itself was mindless.
The long story is I applied for a “full-time, non-contracted” position for my job with the company TWICE and never got hired so the second time they didn’t hire me I quit on the spot. The first time they hired every contractor except me. I should’ve quit then. The second time they chose a contractor who was there for less than a year over me. Months later I found out I was paid at least $30K less than other contractors and regular employees. I was pretty pissed.
Anyway, has anyone else ever had a bad experience like this? It was my first job out of college too but I was definitely overqualified to copy and paste content onto a website.
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2021.10.16 01:04 nightmaresarereal187 I gotta admit this Young Thug album punk is incredible(I eat my words)
I’m eating my words folks. I played this all day. I was skeptical to say the least. I have only heard “lifestyle” by young thug before and we ball with meek mill before this punk album. This kid is talented. There is something special about him. I can’t tell you what it is. But I feel his music. This album reminded me of like a trap wyclef. Only song I didn’t like was the future one. Maybe this era has some rappers who aren’t as bad as I thought. Does any one else know other albums from him that are good?
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2021.10.16 01:04 gif_reposter_bot It took a while to realize that tbh
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2021.10.16 01:04 Abolfazl_Amini 🔥💪🏻
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2021.10.16 01:04 PepeBabinski Sanders blames media for Americans not knowing details of Biden spending plan
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2021.10.16 01:04 Secret-Reaction-6141 [For Hire] Dark Fantasy artist looking for work! Hit me up with your ideas! Prices start at $15
2021.10.16 01:04 BeWaRe_oF_MiKe_D New comp ps4 legends league
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2021.10.16 01:04 Alt4HonestMe How do amp sims work?
I'm a super amateur (I've copied and pasted the code for a few filters, implemented a basic allpass from scratch and built a reverb with it, and understand the concept of a Fourier transform, but don't really understand a much of the discrete calculus/linear algebra) audio developer. I was wondering where I could learn how today's amp sims work (I'm sure it's a lot of ML nowadays) or even just what a good starter project would be to get me familiar with the basic structure.
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2021.10.16 01:04 Time_Face_7077 Help me beat leechmonger.
2021.10.16 01:04 sakurafreddy foto inédita del ViEjas con las TWICE 👌
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2021.10.16 01:04 saltandcactus Poor empty sim rig
2021.10.16 01:04 BonezyGaming After The Storm ( Life Is Strange True Colors Wavelengths Episode Funny Moments )
2021.10.16 01:04 PaigeHellerml Should I buy the 1080 TI
2021.10.16 01:04 M0reWe1ght I guess I’m doing something right! Paph fairrieanum and SVO 7828 (second set of blooms this year!)
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2021.10.16 01:04 champi_on Spotify Playlist of Country Love Songs
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2021.10.16 01:04 mgj0221 Improved but i was aiming for 1500+. Should i retake in December or March?
2021.10.16 01:04 antheezy2013 Possible Miami Trade
2021.10.16 01:04 Slicc12 For Free To Play Users
2021.10.16 01:04 tuaturnstheballova Ian Rapoport on Twitter: Chris Carson to IR, out at least three games
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2021.10.16 01:04 Seekingaloha Just a reminder…With fertilizer shortages starting to emerge, many households can get by with coffee grounds. Gardenias, tomatoes, grass…all thrive with coffee grounds. McDonald’s on upper state and Starbucks provides them for free.
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2021.10.16 01:04 Sgt_Pac Had an idea for a gif, someone made it for me :)
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